Syndrome (184). Accordingly, familial pituitary ACTH-secreting tumors leading to Cushing'sCLINICS 2013;68(7):1039-Inherited endocrine tumors Toledo SP et al.Patients with FH-I/GRA have hypertension, high ACTHdependent aldosterone secretion, renin suppression, and high levels of 18OH-cortisol and 18 oxocortisol. The genetic cause is an unequal recombination of CYP11B1 (11-bhydroxylase)/CYP11B2 (ald